Given what I live with, with Arthur, every day, I have developed a strong, amateur-medical interest in memory loss issues and possible treatments.
This article I found was very interesting – it’s a bit jargon-dense but I have enough background in biology and biochemistry that it’s not complete gobbledy-gook for me:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/
Essentially, the researchers have decided to take a full-on “lifestyle modification” approach to treating early-stage Alzheimer’s and had substantial success at the anecdotal level. They point to next steps in research. Although they often use “AD” and “Alzheimer’s” to refer to the target problem, they seem to have had plenty of success with people suffering cognitive and memory problems who have NOT been explicitly diagnosed with Alzheimer’s.
I considered this paragraph to be the core, best summary of the findings and direction of the research cited.
The therapeutic system described in this report derives from basic studies of the role of APP signaling and proteolysis in plasticity, and the imbalance in this receptor proteolysis that reproducibly occurs in Alzheimer’s disease. There are numerous physiological parameters that feed into this balance, such as hormones, trophic factors, glucose metabolism, inflammatory mediators, ApoE genetic status, sleep-related factors, exercise-related factors, and many others; therefore, the therapeutic system is designed to reverse the self-reinforcing (i.e., prionic) signaling imbalance that we have hypothesized to mediate Alzheimer’s disease pathophysiology.
